Sitagliptin previously identified as MK-0431 and marketed as the phosphate salt under the trade name Januvia is an oral Type 2 diabetes medication manufactured by Merck & Co. This new oral hypoglycemic (anti-diabetic) drug is the top-selling brand in its class. In 2007, an oral combination of sitagliptin and metformin was marketed in the US as Janumet.
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Apixaban with the trade name Eliquis is an orally active, reversible, selective factor Xa inhibitor. Specialist indicates this medication for the treatment of venous thromboembolic events that are taken by mouth.
This anticoagulant prevents thrombin generation and thrombus formation; it decreases the conversion of prothrombin to thrombin. After approval in 2012, Pfizer and Bristol-Myers Squibb developed Apixaban in a joint venture. Apixaban is the third novel oral anticoagulant approved in the U.S. for the management of thromboembolic disease.