Body’s immune system produce Immunoglobulin antibodies which help fight infection and disease. During Intravenous immunoglobulin or IVIG treatment, immune-globulins donated by different people is given by a drip to treat various conditions and immunodeficiency disorders. There are different brands of IVIG available each contain different levels of certain antibodies. Intravenous treatment help to inject sufficient amount of immunoglobulin to reach clinical efficacy. IVIG infusion can have severe localized and systemic adverse effects. Chest discomfort or pain is a Serious IVIG side effect.