Eliquis (Apixaban)

Eliquis in Dano Health

Eliquis (Apixaban) in Dano Health view

Apixaban with the trade name Eliquis is an orally active, reversible, selective factor Xa inhibitor. Specialist indicates this medication for the treatment of venous thromboembolic events that are taken by mouth. This anticoagulant prevents thrombin generation and thrombus formation; it decreases the conversion of prothrombin to thrombin.

After approval in 2012, Pfizer and Bristol-Myers Squibb developed Apixaban in a joint venture. Apixaban is the third novel oral anticoagulant approved in the U.S. for the management of the thromboembolic disease.

Eliquis in Dano Health

Eliquis in Dano Health


In 2012: Apixaban received its approval in Europe.

In 2014:  the FDA approved Apixaban as a treatment and secondary prophylaxis for Deep Vein Thrombosis and Pulmonary Embolism in the U.S.

Medical Uses

Apixaban, this anticoagulant, is indicated for:

  • reducing the stroke and embolism in patients with non-valvular atrial fibrillation, diabetes mellitus, or symptomatic heart failure
  •  treatment of prophylaxis of deep vein thrombosis (DVT) that may lead to pulmonary embolism(PE) in knee or hip replacement surgery patients.
  • reducing the risk of recurring deep vein thrombosis (DVT) and pulmonary embolism (PE) following initial therapy.

Mechanism of action

Harmful blood clots sometimes can be formed in the blood vessels of the legs, lungs, brain or heart, and cause a blockage in a patient who had a surgery or a fast irregular heartbeat.

Apixaban blocks ‘factor Xa’, which involved in the development of blood clots; Through this blocking, it prevents blood from clotting as quickly or as effectively as normal. This selective inhibitor of FXa does not require anti-thrombin III for antithrombotic activity.

This medication has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. Apixaban decreases thrombin generation and thrombus development by blocking FXa.


Eliquis was initially approved for the treatment of both venous thromboembolic events and non-valvular atrial fibrillation. The U.S. FDA approved this drug for the treatment of Deep Vein Thrombosis and pulmonary embolism in 2014. As a result of this approval, Eliquis sales gained momentum and jumped from $146 million in 2013 to $3.3 billion in 2016.

At the first half of 2017, Eliquis exporter announced that its sales reached $2.3 billion; it reflected the growth of 47% over the prior year period. This growth is attributed to higher demand given its increased acceptance and market share gains.

It has also become a leading anticoagulant in new-to-brand prescriptions among cardiologists in the U.S., gaining strong traction among physicians for atrial fibrillation.

Bristol-Myers Squibb’s cardiovascular segment, which primarily consists of Eliquis, accounts for over 15% of the company’s value. According to the estimation, Eliquis will perform well over the next few years at the cardiovascular business. Turkish pharmaceutical wholesalers alongside other suppliers have expected that  Eliquis sales reach a peak of $4.5 billion in 2021. But as the drug nears its patent expiry in 2023, the sales are likely to decline.

Bristol-Myers Squibb and Pfizer, main suppliers of Eliquis co-developed this drug. This partnership with Pfizer gives it a strong global reach.  It was the last new oral anticoagulant to reach the market, but it beats the expectations. This drug is considered safer than warfarin. Eliquis also has outperformed Johnson and Johnson’s Xarelto in terms of total prescriptions in its class. IMS Health Incorporated reported that Xarelto has 46.5% of the NOAC market, compared with a 42.5% share for Eliquis; it represents a decline in share for Xarelto from a peak of about 60% of the market, while it has enjoyed continuous growth in its market share over the last few years.

Bristol-Myers Squibb recently posted its Q1 results. The company’s overall revenues grew 5%, led by Opdivo and Eliquis sales.


Eliquis in Danohealth view-growth of Opvido and Eliquis

Eliquis in Danohealth view-growth of Opvido and Eliquis



Expect Eliquis & Opdivo to Continue to See Strong Growth

The global Apixaban market

Increasing geriatric population, the prevalence of atrial fibrillation in people over 80 years old and increasing incidences of deep vein thrombosis and pulmonary embolism are major factors driving the growth of Apixaban market according to the expectations.

Increasing investment in research and development activities in the pharmaceutical sector and the launch of innovative oral anticoagulant drugs are the other factors fueling market growth. Stringent regulations by governments and the risk of side-effects and complications associated with the use of oral anticoagulants will hinder the growth of the global Apixaban market according to the expectations.

Key players are using various strategies such as mergers, acquisitions, new product launches, expansions, collaborations, partnerships, approvals, and joint ventures to retain its position in the Apixaban market. Some of the main Eliquis distributors and suppliers are Pfizer, Medichem, Polpharma, Beijing Cooperate Pharmaceutical, Centaur Pharmaceutical, Deafarma, and Dipharma Francis.

Also, it should be noted that clinical trial product wholesalers such as Dano Health are providing Eliquis for the companies who are eager to research on this drug.

Researchers segmented the global Apixaban market into North America, Europe, Latin America, Asia Pacific, Middle East, and Africa. North America has the dominant position in terms of revenue creating by the high price of the drug in treating venous thromboembolic events. According to the expectation, Asia Pacific market will witness significant growth followed by Europe market. This growth will be the result of increasing healthcare initiatives by respective governments. The study published PLOS ONE 2016 has shown that the cost-effectiveness of Apixaban drug versus warfarin in Chinese patients with non-valvular atrial fibrillation in Hong Kong is the factors that are also propelling the growth of Apixaban market in the particular region.



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