Clinical Trial

Comparator and Reference Listed Drugs

Before a generic or biosimilar pharmaceutical product (off label drug) could be confirmed for utilizing, it must go through the clinical trial procedure to ensure that it is successful and safe and furthermore that the nature of the item is adequate.

In clinical trials, a comparator drug (characterized as an investigational or marketed item [i.e. Active control] or placebo utilized as a reference in a clinical trial) is regularly required. Comparator studies, for the most part, focus on the effectiveness of a medication which is already available, instead of a placebo. The comparator study is utilized to compare the sufficiency of the investigational item to the existing drug.

To discover qualifying suppliers in a great number of geographically differed markets is a time-intensive assignment that is regularly full of hazard. The comparative drug, along with import/export considerations, summon an entire host of different challenges in the supply network. Throughout the supply chain, the logistics associated with managing comparator drugs has become boundlessly more intricate in recent years.

Dano Health Group Can Take The Hassles and Worries of a Clinical Trial Off Your Hands

“If you require a main Supplier for clinical trial supply of comparator drugs, to give you genuine feelings of serenity that your clinical trial will advance with the correct quantity, of the correct item, in the correct condition, at the ideal time – you’re in safe hands”.

As a full-line wholesaler is continually looking to the future, we cooperate with most pharmaceutical manufacturers to convey medicine to the patients and grow new logistics concepts, Dano Health Group with several active branches worldwide and a strong global network supply any clinical trial requirements. Hence timeliness, cost- efficiency and consistency are the key advantages of our clinical trial services.

Timeliness – Quick and detailed reaction to any demands for quotations.

Consistency – you can see for yourself the incredible performance each time when working with us! We are excited about setting up long-term partnerships.

Challengeable – Experienced in import and export, logistics and distribution.

Extensive Experience – In-depth understanding of clinical trials requirements.

Intellectual – Manage the whole supply chain and offer indicated solutions.

Consolation – Regulatory counsel and supportive documents.

We create ideal individualized solutions by adjusting and combining our services according to the needs of our customers. Our exceedingly adaptable solutions range from small biotech to large pharmaceutical sponsored trials. The point is to guarantee the best logistics setup an ideal clinical trial supply administration for local and worldwide clinical trials. Dano Health Group supplies clinical trials item in both small and large amounts, including comparator drugs, reference listed drugs and unlicensed medicine supplies (early access) in every therapeutic class and dosage shapes.

  • Comparator Drugs (Reference Drug) Services

Is it analytical sample required or branded Innovator Samples/Reference Listed Drugs (RLD) from single/numerous batches, origins – we can provide quick and dependable sourcing solutions worldwide to satisfy Unlicensed Medicines (early access) requirement. Examples of recently launched comparator drugs are Lorbrena, Olumiant, Mektovi, Ajovy, Vitrakvi, Ultomiris.

  • Generics for Clinical Trial Use

Cost- efficiency, numerous choices of producers and quick reaction are among vantages of our services of generics supplies for clinical trial utilize. With a large number in our sell records and steady conveyances to hospital tenders, we are prepared to become your dependable partner to supply generic referral products for clinical trial utilize.

Hospital Therapies

Our product range covers all aspects of caregiving and medical equipment making us the ideal one-stop-shop for Hospitals and clinics. Every healthcare institution has urgent needs to critical drugs in the field of Oncology, IV fluid products, blood derivatives, critical care drugs, and etc.., which must be provided immediately. We aim to provide these hospital products to improve patient’s health and increase life expectancy.

Parenteral IV Fluid Therapy

The most critical requirements for hospitals are parenteral products and their shortage may cause a vital crisis and that is why Dano main skill is supplying the qualified parenteral drug in different regions. Dano is able to supply intravenous products in both LVP (Large Volume Parenteral Products) and SVP (Small Volume Parenteral Products). This kind of therapy is an important and potentially life-saving treatment of many problems with various reasons. Status of the intravascular volumes and then the restoration of total body water and electrolytes is the primary concern of the clinicians. Dano Health Group serves dozens of hospitals within the M.E.N.A countries and we pride ourselves in having the right equipment and dedication to provide these hospitals all the Parenteral IV Fluid products they need to function properly so they can save lives. Products such as Sodium Chloride Injection (Normal Saline & Half Saline) Ciprofloxacin Injection, Dextrose Injection, Paracetamol Infusion, Ringer lactate, Propofol, linezolid, and etc….

Blood Derivatives

Dano Health Group is knowledgeable in blood-determined therapeutics— Dano built its business serving clients and experts whose patients need them to live. Since blood derivatives raw material is human blood, these products usually face shortage globally. Blood derivatives products mostly produce by exclusive manufactures. The main players of this products are Griflos, Baxalta, Octapharm, Kedrion, Biotest, Baxter International, CSL Behring, and other manufacturers. Fortunately, Dano has direct access to these manufacturers through its Italian office.

As a blood-subsidiary product supplier, we experienced in satisfying our clients by providing notable services according to the requirements. We assembled our reputation on it. These products include:

  • Coagulation Factor Products such as (factors X, factors V, factors II, factors I, and factors XIII)
  • IVIG (Intravenous Immune Globulin)
  • Human Albumin
  • RH0(D) Immune Globulins
  • And much more

Critical Care Products

Dano Health Group also supplies critical medications to hospitals and pharmacies. Emergency medicines are commonly used in hospitals to immediately treat and stabilize patients. Emergency cardiac drugs are especially important in ERs and intensive care units. These medicines include Cardiovascular System (Urapidil injection, Levosimedan injection) Central Nervous System (Dexmedetomidine injection, Midazolam injection, Piracetam injection), Anesthetics & Analgesics (Fentanyl injection, Sufentanil injection, Alfentanil injection), Musculoskeletal System (Dexketoprofen injection, Atracurium besylate injection, Rocuronium bromide injection) and other emergency products (Carbetocin injection, B-vitamins complex injection, Pyridoxine hydrochloride injection).

Equipment & consumables

We source the most trusted names in surgical, treatment and medical supplies from Europe and the USA. Dano Health Group provides both the public hospital sector and private clinics with a wide variety of equipment, consumables and other treatment solutions. From the smallest medical centers to the largest metropolitan hospitals, Dano Health Group delivers healthcare supplies accompanied with proven clinical performance, great warranties and high levels of cost-effectiveness.

  • Generic Pharmaceuticals
  • Hospital Equipment
  • Medical Consumables
  • Injection Sets

Named Patient

Named Patient Drugs

Healthcare experts can confront the challenge of treating patients who require a medication that isn’t locally accessible to them. The drug may not be launched in their domain, be discontinued, or would be essentially hard to find. In such cases, doctors and drug specialists need to source and dispense patient-specific, difficult-to-obtain treatment (frequently referred to as named patient medicines), often on an urgent basis. Unlicensed medicines should be recommended by doctors if it is confirmed to them that there are no reasonable licensed choices. This group under the labels of compassionate use, special access, expanded access, or named patient program, these arrangements enable organizations to supply patients with access to their medications while the medications are still in the preapproval stage. Strict regulations governing such access define access criteria, data collection, non-promotion, and control of drug distribution.

Named patient drugs examples are: Ipilimumab )Bristol-Myers Squibb – Yervoy(, Nivolumab (Bristol-Myers Squibb – Opdivo), Pembrolizumab (Merck & Co. – Keytruda), Enzalutamide (Astellas Pharma – Xtandi), adcetris, sovaldi, harvoni, ibrance, imbruvica, soliris, sprycell, jakafi, afinitor, stivarga, alicensa.

Examples of conditions where such access might be allowed include:

  • A drug for which no clinical alternative exists is still experiencing clinical trials;
  • A licensed medicine existed, however, it is ceased, and an unlicensed alternative that exists is still in development;
  • A product is waiting for endorsement by a specific government, however, is authorized in other countries;
  • A local shortage exists for a fundamental medicine; or
  • A patient has a prompt clinical need, yet isn’t qualified for a trial, and the treating health care proficient considers that the patient may profit by taking the medication.

Dano Health Group offers unmatched global performance on operating Named Patient program

Dano Health Group has the expertise and foundation to source these named patient drugs from everywhere throughout the globe, and get them quickly and securely to the patients need them. Access to global commercial database, robust connections to the industry’s leading pharmaceutical supply chains, and a multilingual client services group team all combined makes Dano Health Group preferably set to support healthcare professionals all around the world.

Countless numbers of successful conveyances to worldwide destinations impelled Dano Health Group leadership in managing and serving unmet patient needs through early access mechanisms.

Oncology drugs

What are Oncology drugs?

Oncology is a part of drugs that deal with the prevention, diagnosis, and treatment of cancer. The medications utilized for cancer treatment could be unbelievably complex and that is the reason Dano Health Group; is devoted to offering you with sourcing, supplying and supporting. We stock the majority of recent, most advanced medicines for a wide range types of cancer.

Types of Oncology Drugs

Chemotherapy is the utilization of a drug to treat cancer. Chemotherapy executes cancer cells. It might be utilized to cure cancer, help to hold it from spreading or bring downside effects.

Advanced Methods such as Targeted therapy and immunotherapy are other cancer treatments that utilize to treat cancer.

Standard chemotherapy works by executing cancer cells and some ordinary cells. Targeted treatment and immunotherapy focus in on particular targets (molecules) in or on cancer cells.

Examples of Targeted therapy products are:

Trastuzumab (F. Hoffmann-La Roche AG – Herceptin), Bevacizumab (Genentech – Avastin), Cetuximab (Merck & Co. – Erbitux), Imatinib (Bristol-Myers Squibb – Gleevec), Gefitinib (AstraZeneca – Iressa), Bortezomib (Millennium Pharmaceuticals – Velcade), Olaparib (Merck & Co. – Lynparza), Sunitinib (Pfizer Inc. – Sutent), Thalidomide (Celgene Corporation – Thalomid)

Examples of immunotherapy products are:

Alemtuzumab (Bayer AG – Campath), Ipilimumab )Bristol-Myers Squibb – Yervoy(, Nivolumab (Bristol-Myers Squibb – Opdivo), Ofatumumab (GlaxoSmithKline – Arzerra), Pembrolizumab (Merck & Co. – Keytruda) and Rituximab (Biogen – Rituxan).

Classes of Commonly Used Chemotherapy Drugs

This is definitely not an entire list of chemotherapy drug classes, yet it can offer you a thought of how chemo medicines are grouped and how chemo medicines work in terms of the cell life cycle. These medicines might be joined to assault cancer cells in various ways.

  • Alkylating agents: These sorts of medicines intrude with the manner in which cells work and can execute cells in different phases of the cell cycle.
  • Antimetabolites: These medications influence how a cell functions by supplanting common substances in the DNA that cells need to develop. Without these characteristic substances, cells can’t multiply and ultimately die.
  • Plant alkaloids: These medications are produced from plants. They work by keeping cells from separating in two.
  • Mitotic inhibitors: These medications are produced from plants and other natural items. They work by keeping cells from separating.
  • Antitumor antibiotic: These medications keep cells from duplicating.
  • Topoisomerase inhibitors: These medications stop obvious enzymes that cells need to recreate.

Examples of Chemotherapy products are:

Abraxane (Chemical Name: Albumin-bound or Nab-Paclitaxel), Adriamycin (Chemical Name: Doxorubicin), Paraplatin (Chemical Name: Carboplatin), Cytoxan (Chemical Name: Cyclophosphamide), Cerubidine, DaunoXome (Chemical Names: Daunorubicin), Doxil (Chemical Name: Doxorubicin), Ellence (Chemical Name: Epirubicin), Adrucil Adrucil (Chemical Name: Fluorouracil also called 5-fluorouracil or 5-FU), Gemzar (Chemical Name: Gemcitabine), Halaven (Chemical Name: Eribulin), Ixempra (Chemical Name: Ixabepilone), Amethopterin, Mexate, Folex (Chemical Names: Methotrexate), Mitomycin (Chemical Name: Mutamycin), Novantrone (Chemical Name: Mitoxantrone), Navelbine (Chemical Name: Vinorelbine), Taxol (Chemical Name: Paclitaxel), Taxotere (Chemical Name: Docetaxel), Thioplex (Chemical Name: Thiotepa), Oncovin, Vincasar PES, Vincrex (Chemical Name: Vincristine), Xeloda (Chemical Name: Capecitabine).

Oncology Health Care Solutions Delivered On Time, Every Time!

Offering remarkable service and quality pharmaceutical products for multiple years, Dano Health Group is more than just a wholesaler & supplier company. Our authentic individuals are bringing unmatched support to the pharmaceutical industry through a completely structured supply chain. Providing our services for different oncology brand and generic products manufactured in Europe, Turkey, and India. Dano Health Group is your appropriate pharmaceutical supplier. Get in touch with us today to book your lifesaving drugs at a competitive price.